Rafa Benitez's side travel east after winning only four of their last 12 ties on the road in Europe and with a trip to Old Trafford soon after, key players may be rested
Only Yossi Benayoun (ankle) and Oriol Romeu (knee) are expected to miss out through injury, but John Terry (knee) may not be risked following a fairly stuttering return from a spell on the sidelines.
Benitez's rotation of his strikers suggests Fernando Torres will come back into the team after Demba Ba's goal-scoring appearance against West Brom at the weekend, while Ashley Cole may be rested, allowing for Ryan Bertrand to come back into the side.
Romanian champions Steaua come into the tie with almost a full squad to choose from as Laurentiu Reghecampf looks to continue his side's impressive run in the competition.
Daniel Georgievski (fibula) remains out for the hosts but, aside from the Georgian defender, Steaua can call upon a full-strength side.
Brazilian forward Adi Rocha could come back into the side in place of Stefan Nikolic, while Cristian Tanase should retain his role in the starting line-up despite receiving a red card during the win over Gaz Metan at the weekend.
|DID YOU KNOW?|
Chelsea and Steaua have never faced each other before in a competitive match.
- The Romanians finished top of their Europa League group, above Stuttgart, FC Copenhagen and Ole Gunnar Solskjaer's Molde.
From their last 12 away matches in the Europa and Champions League, The Blues have three wins.
Liverpool were the last side to face the Romanian side, leaving Bucharest with a 1-1 draw in December 2010.
Reghecampf's (pictured right) side have lost only four of their previous 20 home matches in Europe.
Chelsea's group of players includes 19 foreign players, while Steaua have just five.
The average age of Steaua's first-team squad is 24.1, compared to 27 for Chelsea.
Chelsea's two Europa League goals so far this season have been scored in the final 15 minutes of ties.
Steaua have scored eight times in the last 15 minutes of European matches this season, 42 per cent of their overall output.
- Chelsea are 6/1 to beat Steaua 1-0 with Coral.