A second half masterclass from Mourinho's team blew Real Betis away as Gonzalo Higuain continued his rich vein of form with another hat-trick.
Gonzalo Higuain was the hero for Madrid this evening, as he continued his wonderful form in recent weeks. His well-taken hat-trick tonight made it nine goals in four games for club and country in the past 11 days. Kaka netted the home side's other goal.
With the scores still level in the first half, Betis' keeper Casto did well to push Cristiano Ronaldo's devilish cross to relative safety only for Mezut Ozil to hack the ball back towards goal and it was only a decent block from Dorado that ensured the scores remained level.
Betis' best chance of the opening 45 minute fell to Ruben Castro, but he could only volley over from 10 yards out after being found in space inside the penalty area.
It was a disapointing half for the home side, and as the whistle was blown their efforts were met with jeers by an expectant crowd.
It was not long before they broke the deadlock after the interval, however - less than 45 seconds in fact.
Marcelo hooked a wonderful ball to Ronaldo, who exhibited his electric pace to get the wrong side of the defender and pull the ball back to Higuain, who calmly slotted into an empty net from six yards out. In doing so, he continued his rich vein of goalscoring form.
Kaka added a second with a superb effort after Ronaldo found him on the edge of the area after steaming past Chica down the left.
The Brazilian took a touch to set himself and then whipped the ball round Casto and into the bottom corner of the net. He was clearly delighted with his strike, and despite being substituted immediately after, was sporting a grin as he took his place on the bench.
Betis pulled a goal back minutes later after hesitancy in the Madrid area allowed Castro to burst through, and the ricochet fell to Jorge Molina who controlled the ball well and fired past Casillas.
Higuain made it 3-1 on 70 minutes, rounding Casto and slotting home from an acute angle after another glorious assist, this time from the substitute Angel Di Maria.
Di Maria was the provider yet again as Higuain completed his hat-trick, his second in a row in La Liga. The Argentine saved the best til last, lobbing a beautiful finish over Casto's head after racing through one-on-one.
The win for Madrid puts them top for the time being, as Barcelona, who could move above them, take on Racing Santander this evening. Betis meanwhile, will be disappointed to be beaten in such a manner in the second half, and have now recored three defeats in a row.