Lyon have an impressive record against PSG, but the hosts are unbeaten in Ligue 1 this season and have not lost a domestic tie at Parc des Princes in over a year
The reigning champions have won 10 and drawn four of their 14 Ligue 1 fixtures this term - winning their last three in a row - and have not lost in their last 25 league games.
However, while a trip to Parc des Princes - where PSG have not been beaten in the top flight for over a year - would be daunting for most sides, Lyon can have some confidence given their historically strong record against the capital club.
Remi Garde's men have 13 wins to PSG's nine victories in the head-to-head record, although Blanc's charges have won four of the last five Ligue 1 meetings between the clubs and recorded two 1-0 successes last term.
Zlatan Ibrahimovic has been the driving force behind PSG's formidable start to their title defence, with the Sweden international having scored 15 goals in his last nine appearances for the Parisiens in all competitions.
Even though Lyon have won two of their last three matches, they remain seventh in the table after a poor start that saw them collect just two wins from their opening 10 games.
If passed as match-fit, Bafetimbi Gomis will pose the main threat to the PSG defence after scoring three in his last four Ligue 1 outings.
PSG have just one injury concern ahead of the Parc des Princes clash after Blaise Matuidi was struck down with a virus, but the midfielder has not been ruled out completely by Blanc.
Lyon, on the other hand, have problems with five players, as Mathieu Gorgelin (hamstring), Rachid Ghezzal (back), Mouhamadou Dabo (knee) and Yassine Benzia (eye) are all doubts for the visitors, while Anthony Lopes will definitely not feature.