The Hammers head to the KC Stadium without an away Premier League win since March, while Capital One Cup hero Ricardo Vaz Te is pushing for a start after scoring against Cardiff
Steve Bruce's side picked up an impressive win last weekend against Newcastle United, and after victory in the Capital One Cup over Huddersfield in midweek, they will be brimming with confidence.
And they will be hopeful of collecting their third league triumph of the season against West Ham, who have won just three of their last 20 away Premier League games.
However, Sam Allardyce's side have emerged victorious in 17 of their 41 meetings with Hull and they are unbeaten in their last five meetings – winning four.
Both sides have started the season steadily, and come into the clash on the back of midweek Capital One Cup wins.
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|17/2||Ricardo Vaz Te is 17/2 with bet365 to open the scoring against Hull
With Andy Carroll out injured, Modibo Maiga struggling for goals and Mladen Petric still some way off full fitness, Vaz Te could be the man West Ham need to record their second league win of the season.
"He keeps on telling everyone that he creates chances and scores and that's what the manager wants - people to put the ball in the back of the net," assistant manager Neil McDonald said after the Cardiff victory.
"That's a knock on the door for the manager, he's available on Saturday against Hull and gives the manager a nice little problem.
"You have to forget what happened in the past, maybe it was bad advice, but he's a genuine lad who just wants to play.
"He wanted to go and play somewhere but he got a game here and scored the winner which is great."
Meanwhile, Bruce looks set to be without Maynor Figueroa (compassionate leave), James Chester (hamstring), Robert Koren (foot) and Paul McShane (knock), while there are doubts over Robbie Brady (stomach).
One positive for the Hull boss is the return to fitness of Joe Dudgeon – the defender completing 90 minutes against Huddersfield on Tuesday – and the continuing improvement of Egyptian striker Gedo.
West Ham have Carroll (foot) and Alou Diarra (knee) out with long-term injuries, but Joe Cole (hamstring), Guy Demel (thigh) and Stewart Downing (leg) could all feature.