A five-star performance from Luiz Felipe Scolari's side secured an impressive victory in a hotly-contested friendly against the Central American outfit in Miami
The result was Brazil's fifth straight win since a shock loss to Switzerland in August, a period in which Luiz Felipe Scolari's men have scored 18 goals.
For Honduras, the result ended a four-match unbeaten run, but coach Luis Suarez will no doubt be desperate to improve their defence ahead of the World Cup.
The Selecao took the lead on 22 minutes when Paulinho crossed for Bernard to power home the game's first goal.
Dante then nodded home a Neymar free kick to double Brazil's lead 10 minutes after the half-time, with the Bayern Munich man's attempt on goal deflecting off Honduras' Wilson Palacios and Carlo Costly before trickling into the net.
Maicon then added a third as he tapped into an empty net after Paulinho's close-range effort was blocked.
Substitute Hulk teed up Brazil's fourth goal when his cut-back pass found Willian, who guided his shot across Honduras goalkeeper Noel Valladares.
Hulk himself made it 5-0 in the 74th minute with a well-placed finish after neat backheels from both Ramires and Robinho.
Roger Espinoza and Maynor Figueroa were at fault for Brazil's first, gifting Paulinho space on the right to send in a cross to winger Bernard - who powerfully tucked away the opportunity.
There was some earlier concerns for Scolari, however, as superstar Neymar pulled up sore from a first-minute challenge.
The Barcelona forward shook off the knock to his right knee, though, much to the pleasure of the Sun Life Stadium fans who he went on to impress with some fancy footwork.
Neymar could have made it two goals late in the first half with two sights on goal - the first was saved strongly by Valladares in the 37th minute.
Four minutes later, Neymar dribbled his way into the area and was crashed into from behind, but referee Dave Gantar waved away the penalty appeal.
Brazil took full control of the contest in the second half, and converted that dominance to the scoreboard in the first 30 minutes after the restart.
Honduras were left to rue some flat-footed defending, but Scolari will be delighted with his side’s capacity to convert their chances into goals.
Brazil continue their preparations for the World Cup when they face Chile in Toronto on Tuesday.