The Nerazzurri are looking for a fifth win in six Serie A games this season but visit a ground where they have not won since 2010
Walter Mazzari has made a fine start to life as Inter coach, with their win over Fiorentina on Thursday making it four league wins from five outings for the former Napoli boss.
Only league leaders Roma - who have yet to drop a point this season - post a better record than Inter, and Mazzarri's side head to Sardinia knowing they can briefly overtake the capital club at the summit of the division.
Rodrigo Palacio has led the way for Inter on the goalscoring front, with the Argentine striker scoring three times thus far.
Yet Inter are likely to face a difficult test at the Stadio Is Arenas, a venue where they have not won since 2010, with Samuel Eto'o scoring the only goal of the game in a 1-0 win for a team then coached by Rafael Benitez.
Cagliari should also take great confidence from their performances against Inter last season: under Ivo Pulga, the Rossoblu claimed four points from the two fixtures, with Mauricio Pinilla netting a double in a 2-0 home win back in April.
Indeed, Cagliari claimed a number of scalps in front of their home fans in the previous campaign, also overcoming the likes of Lazio and Fiorentina.
However, Diego Lopez's side have taken just six points from their first five games in 2013-14, although all of their last three outings have ended in draws.
Defence has been the main problem for the Sardinians, who have yet to keep a clean sheet in any competitive game this term. Given that Inter have scored 15 goals in the league to this point, they should be hopeful of adding to that tally on Sunday as they look to continue their revival under Mazzarri.