The situation is as unique as it is extraordinary and Camp Nou is a fittingly dramatic setting for what should be quite a spectacle between Barcelona and Atletico Madrid.
Given the side from the Spanish capital are ahead of the Catalans in the league table, Atletico know that a draw would be good enough for them to win the league for the first time in 18 years, while Barca must win to lift the title.
This will be the sixth meeting between the sides this season, with the previous five encounters seeing four draws and an Atleti win.
Diego Simeone's men are marginal outsiders to win the crown priced at evens (2.00), with bet365 while Barca are offered at 5/6 (1.83) to retain their Primera Division crown.
Elsewhere, at the bottom of the table, two side from five will join Betis in the Segunda Division next season with the biggest game seeing 19th-placed Valladolid host 17th-placed Granada.
The hosts suffered a catastrophic 4-3 defeat at Betis last weekend and need a win to stand any chance of avoiding the drop, yet things do not look good for Valladolid, who are the 1/4 (1.25) to go down.
However, they will take heart from the fact that they are unbeaten at home in 12 games and have caused Barcelona and Madrid some real problems at the Estadio Jose Zorrilla.
If they win, Granada will go down and the price of 5/6 (1.83) for the Andalusians to be relegated looks worthy of some consideration.
Elsewhere in the betting, badly out of form Osasuna are offered at 8/13 (1.62) to remain in the relegation zone come the end of their home game with Betis, while the outsiders for the drop are Getafe at 13/2 (7.50) and Almeria at 22/1 (23.00).
|Granada to be relegated at 5/6 (1.83) for a 2.5pt stake with bet365