The Selecao - who have won this competition on the last two occasions - come into the Group A game on the back of a 3-0 over France after their 2-2 draw with England and are 3/10 (1.30) with Paddy Power to see off 9/1 (10.0) shots Japan.
A Brazilian has won the ‘golden shoe’ prize for top-scorer in four of the last six tournaments and European football fans in particular will be keeping an eye on the competition's poster boy Neymar, who has just completed a move to Barcelona from Santos.
The 21-year-old - who’s hit the net 20 times in 34 games for Brazil since making his international debut in 2010 - is 7/2 (4.50) to open the scoring on Saturday night and the same price to get the last goal of the game.
Meanwhile, Mexico take on Euro 2012 finalists Italy on Sunday night in the second Group A match and desperately need to improve upon their recent performances to get a result.
With just one victory and five draws to date in their World Cup qualifying group they lie third - just a point ahead of Honduras – albeit still in a guaranteed qualification spot.
Paddy Power, however, are going firmly with the form guide, and make Italy the 6/5 (2.20) favourites with Mexico priced at 12/5 (3.20).
Manchester United striker Javier 'Chicharito' Hernandez has 30 goals in 46 games for his country, including five in their last 10 World Cup qualifiers, and is 6/1 (7.0) to get the first goal of the game and the same price to strike last with the online bookmaker.
On Sunday night, Uruguay take on world champions Spain in the later game in Group B and will be relying on Luiz Suarez to rattle the onion bag.
The Liverpool striker’s 32 goals in 64 games for his country make him their most potent weapon in a game where Spain – who beat Ireland 2-0 in New York earlier this week - are overwhelming favourites at 8/13 (1.63), with the South American side at 5/1 (6.0).
Suarez is 7/1 (8.0) to score the last goal of the game and that’s not a price that would have been seen in the Premier League last season, where he scored 23 league goals for the club before a nibble on Chelsea defender Branislav Ivanovic’s arm earned him a 10-game ban.
There should be plenty of attractive, attacking football on offer in this summer's tournament, but paying special attention to the deadly trio of Neymar, Chicharito and Suarez could ultimately pay huge dividends for punters.
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Jim Knight is Betting Editor at Goal.com and has been tipping football games since he was old enough to place a bet. He is a Leicester City fan, writer and member of the We Are Going Up Podcast