The newly instated Republic of Ireland managerial team will take the reins for the first time in the friendly fixture against Latvia in Dublin on November 15
O'Neill will be officially unveiled as the successor to former Ireland manager Giovanni Trapattoni on Saturday November 9, while Keane will act as assistant manager to the 61-year-old.
Speaking to ITV ahead of the Uefa Champions League clash between Real Sociedad and Manchester United, O'Neill hinted that the pair would be a strict managerial team, joking that he would be the "bad cop" while Keane would play the "bad, bad cop."
"[Keane] is coming with me," confirmed the former Celtic and Aston Villa boss. "Personally speaking I think he'll be great for me but more importantly he'll be great for the Republic of Ireland.
"I'm the bad cop and he's the bad, bad cop. We're excited by it," added O'Neill.
Keane revealed that he was "honoured" to be asked by O'Neill to be his assistant and said that he was keen to get started on the task of guiding the team to Euro 2016 in France.
"[It's] fantastic news. I'm delighted, honoured that Martin asked me to help him with the team," said the former Manchester United captain.
"[I'm] very excited and I'm looking forward to working with the players and trying to get them to the Euros."
O'Neill and Keane's first game in their new roles will be in a friendly encounter against Latvia in Dublin on Friday November 15.