The Italian tactician has announced an extended squad ahead of forthcoming international fixtures against Spain, England, Georgia and the Faroe Islands
Pilkington is in line to pick up his first cap for Ireland after being forced to withdraw from previous squads through injury.
Crystal Palace defender Damien Delaney has been recalled, as has Derby County centre back Richard Keogh.
Wolves striker Kevin Doyle and Aston Villa defender Ciaran Clark miss out through injury, but Hull City defender Paul McShane returns to the squad after helping the Tigers secure promotion to the Premier League.
There is no place for Richard Dunne, who has struggled to regain fitness, while Everton midfielder Darron Gibson is another absentee.
Ireland will take on England at Wembley on Wednesday, May 29, before facing Georgia in the Aviva Stadium four days later on Sunday June 2.
The Boys in Green will then welcome the Faroe Islands to Dublin for a World Cup qualifier on Friday, June 7 before flying out to the United States where they will take on reigning world and European champions Spain at New York's Yankees Stadium on June 11.
Full Ireland squad
Forde, Westwood, Randolph, O'Shea, St Ledger, Delaney, R. Keogh, Wilson, Coleman, Kelly, O’Dea, McShane, Whelan, McCarthy, Green, Hendrick, McGeady, Pilkington, McClean, Brady, Meyler, A. Keogh, Keane, Long, Sammon, Walters, Cox, Hoolahan