The Leesiders travel to Oriel Park seeking a win to propel themselves up the table, but manager Tommy Dunne is not expecting an easy game
The Leesiders travel to Oriel Park on the back of a Setanta Sports Cup semi-final elimination after losing on away goals to Shamrock Rovers and will be without defensive duo Kevin Murray and Dan Murray, while midfielder Colin Healy is also set to miss out.
"It will be a difficult game," Dunne told the club's official website. "There has not been much in it in any game we have played, and I don't see this being any different."
After defeating Bohemians in their last league game, Dundalk currently find themselves in fourth place in the Airtricity Premier Division with 15 points from nine games.
Stephen Kenny will have to contend with the absence of John Dillon, who is serving a suspension, while Chris Shields and Eoghan Osbourne look set to miss the tie through injury.
The Lilywhites will, however, be able to call upon goalkeeper Peter Cherrie and striker Kurtis Byrne after the pair recovered from injury concerns.
Dundalk host Cork City at Oriel Park on Friday, April 26. Kick off 19:35 BST.