Three first leg ties will get underway while holders Crusaders will seek to overturn a one-goal deficit in the second leg against Cork City
By Ryan Kelly
Crusaders (0) v (1) Cork City (Second Leg)
Tommy Dunne's Cork City will look to secure their place in the Semi-Final when they travel to Seaview for the second leg of their quarter-final clash against Crusaders.
Carrying a one-goal advantage, the Leesiders will be without Kalen Spillane who was sent off in the first leg, while John Dunleavy, Colin Healy and defensive duo Dan Murray and Darren Dennehy are all unavailable due to injury.
Cup holders Crusaders, meanwhile, will welcome back their captain, Colin Coates, for the second leg, after the defender missed the first leg due to a suspension. Gareth McKeown will miss the tie due to injury, while Stephen McBride will serve a suspension.
Derry City v Drogheda United
Declan Devine's Derry City play host to Mick Cooke's Drogheda United in the first leg of the quarter final, as competitive football returns to the Brandywell for 2013.
Last year's runners-up Derry City will be without the influential presence of midfielder Barry Molloy, who will miss the game due to suspension, while Dermot McCaffrey, Michael Duffy and new signing Sean Houston are fitness concerns.
Drogheda boss Mick Cooke must contend with the absence of Alan McNally, who is still recovering from an injury, but will otherwise have a full panel to choose from, with new signing Mick Daly in line to play.
Sligo Rovers v Glentoran
Airtricity Premier Division champions Sligo Rovers welcome Glentoran to the Showgrounds in a repeat of the 2012 Quarter Final which saw the Bit O'Red emerge victorious over the two legs, winning 3-1 on aggregate.
Sligo will be without the services of striker Danny North, who remains sidelined with a knee injury and defender Seamus Coneely will also miss out. However Ian Baraclough will be able to call upon new signings Anthony Elding, Evan McMillan and Aaron Greene.
Glentoran defeated St Patrick's Athletic in the First Round to progress and boss Eddie Patterson has indicated that he will make a number of changes ahead of the clash.
Shamrock Rovers v Linfield
After overcoming Coleraine in the First Round, Trevor Croly's Shamrock Rovers face stern opposition in the form of Irish Premiership champions Linfield in the quarter final.
The Hoops may be without striker Mark Quigley, who scored against Coleraine in the previous round, while Gary McCabe is also unlikely to play a part in the fixture due to illness.
Linfield, who won the inaugural Setanta Sports Cup in 2005, will be without Mark McAllister and Michael Gault, both of whom will serve suspensions from last year's competition.