Shamrock Rovers are hoping to overturn a 1-0 deficit against Coleraine, while St Pat's' scoreless draw with Glentoran at Richmond Park sets up an exciting second leg
By Ronan Murphy
Cliftonville v Cork City
Tommy Dunne's Cork City recorded a comfortable 4-0 victory over Irish League leaders Cliftonville in last week's first leg at Turners Cross, and Reds boss Tomy Breslin will need a small miracle at Solitude to overturn the deficit.
Ian Turner struck twice for the Leesiders in the home game, while Daryl Kavanagh also scored his first goal for his new club. Strong forward Liam Boyce caused problems for the Cork defenders, but could not replicate his league form, where he has 20 goals this season for the Belfast side.
Cork have a number of players ruled out of the second leg, with Brian Lenihan and Darren Dennehy missing the trip due to injury, and John Dunleavy and Stephen Kenny absent with the flu. Veteran midfielder Colin Healy is also a doubt, while Dan Murray is forced to miss out because of work commitments.
Portadown v Drogheda United
Mick Cooke's Drogheda United travel to Shamrock Park, holding a narrow advantage over Portadown after an exciting encounter at Hunky Dorys Park.
Brennan brothers Ryan and Gavin were both on target in the first leg, while new signing Paul O'Connor also scored in the 3-2 victory. Goals from Aaron Burns and Kevin Braniff kept Ports in the tie, despite going two down in the first 14 minutes.
Portadown lost 2-0 to Dungannon Swifts on Saturday in the league, and Drogs manager Mick Cooke is hoping that his opponents will be tired after that tie. Alan McNally and Brian Gannon are both absent from Drogheda's selection due to surgery.
Coleraine v Shamrock Rovers
Trevor Croly's first competitive game in charge of Shamrock Rovers ended in a disappointing loss as North West Senior Cup champions Coleraine took a narrow 1-0 victory back to the Showgrounds.
David Scullion scored the only goal of the game, with Mark Quigley disappointing on his debut for the Hoops. Croly has no major absentees for the trip to Derry, which has been switched to a 19.30 GMT kickoff due to television coverage.
Likewise, Bannsiders boss Oran Kearney has no fitness concerns, despite his side being in action on Saturday, defeating Ballymena United 1-0.
Glentoran v St Patrick's Athletic
Liam Buckley's St Patrick's Athletic travel to the Oval in Belfast after a scoreless draw at Richmond Park in the first leg. Glens goalkeeper Elliott Morris was on hand to deny Jordan Keegan in injury time, and set up an exciting encounter in the second leg.
John Russell missed the first leg due to the red card he picked up against Cliftonville last season in the competition, and will also be banned for the return trip. Kenny Browne is likely to miss out with an ankle injury, but Greg Bolger looks to have recovered in time for the First-Round decider.