St Patrick's Athletic midfielder Chris Forrester is set to pick up his first cap, while Derby County defender Mark O'Brien has also been included in the squad
Among those included in the squad is Bradford City defender Carl McHugh, who earns his first call up to the under 21 squad after helping his club reach the Capital One Cup final. Also earning his first call up is St Patrick's Athletic midfielder Chris Forrester and the 20-year-old represents the only domestically-based inclusion.
Everton defender Shane Duffy has been named in the panel after missing out on a place in Giovanni Trapattoni's senior squad, while Manchester United centre back Sean McGinty is set to pick up his first under 21 cap.
The game will take place at Tallaght Stadium on February 6, and the game kicking off at 13.00 BST. The Football Association of Ireland (FAI) has confirmed that fans holding a ticket for the senior international friendly against Poland on the same day will receive free access to the game.
Republic of Ireland under 21 squad to face the Netherlands
McCarey (Wolves), McDermott (Sandnes Ulf), Duffy (Everton), McGinty (Manchester United), O'Connor (Burton Albion), Williams (Aston Villa), O'Brien (Derby), Doherty (Wolves), Shaughnessy (Aberdeen), McHugh (Bradford City), Bolger (Leicester), Reilly (Birmingham), O'Sullivan (Blackburn), Ferdinand (Peterborough), Carruthers (Aston Villa), Sutherland (Portsmouth), Forrester (St Patrick's Athletic), Forde (Wolves), Murray (Watford), O'Brien (Millwall), Smith (Watford)