The Candystripes boss has a number of injury concerns ahead of the clash at Tolka Park, while Shels enjoy a clean bill of health
After meeting last Sunday at the Brandywell a 1-1 draw between the two teams ensured that the tie went to a replay and Shelbourne boss Alan Mathews admitted that it was a 'difficult game'. An early David Cassidy goal gave the Dublin outfit the lead before David McDaid equalised in the second half for Derry City.
"It was a difficult game for us on Sunday with a lunchtime kick-off. But the lads adapted really well and we at least deserved the draw. We have no injury worries or players suspended," said Mathews.
While Shels have no injury concerns, Derry City could be without a number of players, including striker Rory Patterson and midfielder Barry Molloy, with both individuals sustaining minor injuries in the first semi-final.
Nevertheless, Candystripes boss Declan Devine said that there is no 'fear factor' in his squad as they faced into a replay at Tolka Park.
"We passed the ball very well and asked questions of their back four (on Sunday). That's what we want again come Wednesday night," Devine told BBC Radio Foyle.
"We respect going away from home against good opposition and it's going to be a very difficult game. But in terms of fear factor, there is none."
Shelbourne host Derry City in the FAI Cup semi final replay at Tolka Park, with the game kicking off at 20.00 BST. The winner of the tie will face St Patrick's Athletic in the final at the Aviva Stadium.