Rafa Benitez makes three changes following his side's 3-0 win over Fulham on Wednesday, while Stewart Downing replaces Daniel Sturridge for Brendan Rodgers' side
Despite scoring twice against Fulham in Chelsea's 3-0 victory on Wednesday, the 32-year-old is replaced by Cesar Azpilicueta, while Branislav Ivanovic and David Luiz form a centre-back partnership.
Frank Lampard also drops to the bench after starting against Fulham, while John Obi Mikel replaces the England international in central midfield.
In attack for Chelsea, Fernando Torres starts against his former club, while Oscar is preferred to Victor Moses on the right flank.
For Liverpool, Brendan Rodgers makes only one change after his side's goalless draw at Reading on April 13 as Stewart Downing replaces Daniel Sturridge in attack.
Liverpool: Reina; Johnson, Agger, Carragher, Enrique; Lucas, Gerrard, Henderson; Downing, Suarez, Coutinho.
Subs: Jones, Skrtel, Coates, Shelvey, Coady, Assaidi, Sturridge.
Chelsea: Cech; Azpilicueta, Ivanovic, Luiz, Bertrand; Ramires, Mikel; Hazard, Mata, Oscar; Torres.
Subs: Turnbull, Ferreira, Terry, Lampard, Benayoun, Moses, Ba.