Sir Alex Ferguson has made six changes to the side which beat Braga 3-1 in Wednesday's Champions League clash.
Rio Ferdinand, Rafael Da Silva, Paul Scholes, Michael Carrick, Ashley Young and Robin van Persie all start at Villa Park, with Nani being forced to sit out after suffering a hamstring injury.
Paul Scholes starts ahead of young England international Tom Cleverley in the centre of midfield and in-form striker Javier Hernandez once again begins on the bench despite scoring on Wednesday night.
For Aston Villa Darren Bent remains sidelined with an ankle injury despite reports that he may feature.
The only change from the team that won 1-0 at Sunderland is defender Enda Stevens being bought in for Joe Bennett who is suffering from a knee injury.
Aston Villa: Guzan; Lowton, Clark, Stevens, Vlaar; Westwood, Bannan, Ireland, Weimann; Agbonlahor, Benteke.
Subs: Given, Albrighton, Holman, Delph, El Ahmadi, Bowery, Williams.
Manchester United: De Gea; Rafael, Smalling, Ferdinand, Evra; Valencia, Carrick, Scholes, Young; Van Persie, Rooney.
Subs: Lindegaard, Buttner, Anderson, Cleverley, Fletcher, Welbeck, Hernandez.