The Reds goalkeeper's return from a hamstring injury sees him only on the bench as several youngsters make their Merseyside derby bow, while Marouane Fellaini is fit for the hosts
The injured Glen Johnson is absent from the squad entirely, with Jose Enrique replacing him at left-back and youngster Andre Wisdom on the right of the back four.
It is the right-back's first start in the famous derby, with the same going for Reds starlets Raheem Sterling and Suso.
The hosts are boosted by the return of Marouane Fellaini, with Kevin Mirallas expected to fill in on the left flank for Steven Pienaar, who is suspended after a red card against QPR.
Everton starting XI: Howard; Coleman, Jagielka, Distin, Baines; Naismith, Neville, Osman, Mirallas; Fellaini; Jelavic.
Subs: Mucha, Heitinga, Hibbert, Oviedo, Hitzlsperger, Gueye, Vellios.
Liverpool starting XI: Jones; Wisdom, Skrtel, Agger, Enrique; Gerrard, Allen, Sahin; Sterling, Suarez, Suso.
Subs: Reina, Carragher, Shelvey, Coates, Downing, Henderson, Assaidi.