Jonjo Shelvey has been handed a surprise start by Brendan Rodgers as Liverpool take on Manchester United at Anfield.
Shelvey caught the eye with a two-goal cameo for the Reds in Thursday's Europa League clash against Young Boys, and takes a starting place alongside fellow youngsters Martin Kelly and Raheem Sterling.
United, meanwhile, are without captain Nemanja Vidic, despite the Serb playing the full 90 minutes against Turkish giants Galatasaray on Wednesday.
In his absence, Rio Ferdinand partners Jonny Evans in the heart of the Red Devils' defence, while Anders Lindegaard is preferred to David de Gea in goal and Robin van Persie leads the line.
Liverpool (4-3-3): Reina; Kelly, Skrtel, Agger, Johnson; Allen, Gerrard, Shelvey; Borini, Suarez, Sterling.
Subs: Jones, Enrique, Sahin, Assaidi, Henderson, Carragher, Suso.
Manchester United (4-2-3-1): Lindegaard; Rafael, Evans, Ferdinand, Evra; Carrick, Giggs; Valencia, Kagawa, Nani; Van Persie.
Subs: De Gea, Anderson, Hernandez, Welbeck, Scholes, Cleverley, Buttner.