The £24 million forward will have to wait at least a short while for his debut after completing his transfer from Arsenal on Friday, while Nikica Jelavic is alone up front
Michael Carrick begins the game as a makeshift centre-back alongside the recently recovered Nemanja Vidic as an early-season injury crisis disrupts the Red Devils' ideal back line.
Dimitar Berbatov, who has expressed a desire to leave Old Trafford, is among the substitutes nonetheless while Chicharito is not present, having represented Mexico against USA in midweek.
For the hosts, new signing Steven Naismith is on the bench as Marouane Fellaini is set to play behind centre forward Nikica Jelavic. Recently acquired £6 million man Kevin Mirallas was not signed in time to take part in the Toffees' first game of the season, however.
Everton starting XI: Howard, Hibbert, Jagielka, Distin, Baines, Osman, Neville, Gibson, Pienaar, Fellaini, Jelavic
Subs: Mucha, Heitinga, Naismith, Gueye, Barkley, Coleman, Anichebe
Manchester United starting XI: De Gea, Valencia, Carrick, Vidic, Evra, Cleverley, Scholes, Kagawa, Nani, Welbeck, Rooney
Subs: Lindegaard, Rafael, Anderson, Berbatov, Young, Van Persie, Wootton