The forward left the Etihad Stadium on crutches and was wearing a protective boot following a heavy challenge with Manchester City midfielder Nigel De Jong
The 21-year-old was involved in a heavy challenge with Dutch midfielder Nigel De Jong during United's 1-0 defeat to Manchester City, which has resulted in Roberto Mancini's men leapfrogging the champions into top spot in the Premier League.
Early reports indicate that Welbeck sustained an ankle injury following the tackle from De Jong, but the extent of the forward's knock has not been confirmed.
The injury could also be an early blow for Roy Hodgson, who is expected to be appointed as England boss after holding positive talks with the Football Association on Monday, as Welbeck is expected to feature in Euro 2012 warm-up games against Norway on May 26 and Belgium on June 2.
Welbeck, who has scored 12 goals this season, played 32 minutes of Manchester United's defeat against title rivals City after failing to make the starting line-up.