Real Madrid were dumped out of the Champions League by Borussia Dortmund in the semi-finals last season but will fancy their chances of lifting the trophy for a 10th time this term.
With Carlo Ancelotti now at the helm, los Blancos have enjoyed a fruitful summer of recruitment, with
Isco, Asier Illarramendi and Gareth Bale the club's stand out signings over the summer.
Galatasaray ended their 12-match winless streak against Spanish opposition when they played Real in the quarter-finals last season, as they recorded a 3-2 home victory that ultimately proved in vain as Mourinho's men progressed 5-3 on aggregate.
With Ronaldo on a run of 21 goals in his previous 19 Champions League matches, the Turkish side face a tough challenge in securing a repeat success.
Yet Galatasaray do boast a fine recent record in Istanbul, losing only two of their last 14 home European matches.