The 31-year-old has been ruled out of matches for club and country, joining Lacina Traore on the Toffees treatment table, though a "refreshed" Romelu Lukaku returns to the squadEverton manager Roberto Martinez has revealed that Phil Jagielka will be sidelined for the weekend match against West Ham, as well as England's friendly against Denmark.
The centre-back has missed just two Premier League games this term but picked up a hamstring problem in the past couple of days.
It means Jagielka will miss the Wembley friendly on March 5, with Roy Hodgson set to announce his squad for the fixture on Thursday afternoon.
Martinez told reporters: "Phil has felt his hamstring over the last couple of days and will be missing at the weekend and for England.”
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He added: "Today we will discover the best possible route to go down in terms of the treatment for Lacina. We're working with Monaco."
Everton have lost three of their last four top flight games, including two narrow 1-0 defeats to Tottenham and Chelsea, but Martinez believes his team can take heart from their performances, if not points.
"We haven't been able to get the results our performances have deserved recently and that's something we need to work on," he said.
"The only focus we have is to get as many points as we can between now and the end of the season and get where we deserve to be.
"We know we'll have to be at our best against West Ham but we're happy to be at Goodison and know we can count on our fans.
"West Ham are in a good run of form and we're going to see a side full of confidence. Sam Allardyce deserves a lot of credit."
Martinez also paid tribute to the returning Romelu Lukaku, who has missed the entirety of February with an ankle injury, adding: "I'm really excited about seeing Romelu again. It's been the most demanding season of his career and the break has refreshed him."