The former Marseille trainer has told les Bleus to go for the three points against the current world and European champions, and says they will have to be at their best to win
Les Bleus have won both of their games so far in Group I, beating Finland and Belarus, whilst La Roja scraped past Georgia in Tbilisi.
However, Deschamps - who captained France to a 1998 World Cup triumph - has said that whilst a point would not be at all bad, his side will not go to Madrid aiming for it.
"We cannot play for a draw. Of course, if at the end of the match, there is a draw, we will be happy," Deschamps told TF1's Telefoot programme.
"But we cannot go there to wait for them. In these circumstances, we can concede a goal at any time. Even if we don't sit back, the Spanish [will] force us to.
"The equation is simple, we will have to be at 100 per cent and hope they are not. Let's make them [have] doubts when we have the ball.
"I think the worst thing is to stay in an intermediate position. With the addition of the two full-backs, and the spaces they may have, they can be very dangerous. We will have to create the density in midfield, and try to minimise the gaps and spaces."
In a re-match of the Euro 2012 quarter-final, France play Spain at the Vicente Calderon on October 16.