The Dutchman sustained a knock in his last outing against Rothosen, and has conceded it could rule him out of the clash against the champions - a club he was previously linked to
The Foals claimed a 2-2 draw against the visitors courtesy of an injury-time equaliser, but could be without their record summer acquisition when they travel to face holders Dortmund on Saturday.
"I got a nasty kick on my foot against Hamburg," De Jong told Express.
"It hurts a lot. I do not know if I can play against Dortmund."
The former Twente man was linked with a transfer to Dortmund prior to his switch to Monchengladbach, something the striker claims to be unaware of.
He added: "I know nothing [about that].
"It would be a shame if I could not play against Dortmund. It is an experience for any footballer."
Kick-off on Saturday is scheduled for 18:30 CET.