BVB defeated Wolfsburg 3-1 on Saturday to maintain their three-point advantage over Jupp Heynckes' men, with the top two meeting in midweek.
The Germany international centre-half is looking to strike a decisive blow to Dortmund’s closest rivals.
"If we win, I do not think they can take the title from us," he told Bild.
"If we lose, we are tied. A preliminary decision [on the eventual winners] is thus ready to fall in our favour."
Dortmund head coach Jurgen Klopp added that he wants the game to be a spectacle for the home team’s fans.
"The three points are there to pick up, which is what we want. In any case, we want to offer the 80,000 fans a spectacle," he stated.
Hummels has been a key member of the Dortmund team this season, making 29 Bundesliga appearances so far.