The giant Swede is given the nod despite his impending league suspension, while the Bianconeri skipper gets another starting XI slot in the knockout competition
Despite his impending league suspension for being sent off against Napoli on Sunday, the 30-year-old Swede will be asked to provide the focus for a slightly rotated Rossoneri line-up, with Marco Amelia, Urby Emanuelson and Stephan El Shaarawy among those called into the first XI.
Juve feature club skipper Alessandro Del Piero in their side after his storming performance in the quarter-final win over Roma last month, while new signings Martin Caceres, Simone Padoin and Marco Borriello also start.
The first leg match kicks off at 20.45CET at San Siro.
Milan (4-3-1-2): Amelia; Bonera, Mexes, Thiago Silva, Antonini; Ambrosini, Van Bommel, Emanuelson; Seedorf; Ibrahimovic, El Shaarawy.
Juventus (3-5-2): Storari; Barzagli, Bonucci, Chiellini; Caceres, Giaccherini, Pirlo, Padoin, Estigarribia; Borriello, Del Piero.