The 23-year-old has become the first Real Madrid player to make his international debut for the world champions since Raul Bravo in 2002
The 23-year-old replaced club team-mate Sergio Ramos in the 59th minute of the 2-2 draw with Chile in Switzerland, making him the first Blancos player to make his national team bow for the world champions since defender Raul Bravo 11 years ago.
Nacho, who has made only 12 senior appearances for the Spanish giants, was a late addition to the squad following injuries to other members of Vicente del Bosque's squad.
And he was moments away from tasting defeat, but Jesus Navas came to the rescue, equalising in the dying seconds of the match.
Eduardo Vargas had twice given Chile the lead in the first half after Roberto Soldado had briefly levelled, but Jorge Sampaoli's men were denied what would have been their first-ever victory over the reigning world champions.