The Blaugrana were beaten 1-0 in the first leg at Stamford Bridge, before recording another loss at the weekend at home against Real Madrid.
Nevertheless, Cruyff is confident that they will bounce back in Tuesday's second leg at Camp Nou.
"I still think Barcelona will beat Chelsea on Tuesday," Cruyff wrote in his weekly column in De Telegraaf.
"Despite the fact that Barcelona have now lost two games in a row, I expect another good game from them at Camp Nou.
"You can't compare the loss against Real Madrid to the defeat versus Chelsea. Barca created plenty of chances in London, but failed to convert any of their opportunities. There were hardly any serious chances against Madrid, because the simple things went wrong.
"They will get plenty of chances again in the return versus Chelsea, and I don't think they will again fail to find the net."
Tuesday's encounter kicks off at 20.45CET.