The 40-year-old coach has confirmed the Spanish striker will not feature against the Catalan club on Sunday due to a muscle problem
Soldado has missed Los Che's last two league games and despite training this week, Emery has confirmed that the striker will not be involved in the encoounter with Mauricio Pochettino's men.
"He is eager to play and has the desire but from a medical position, it is better not to force the issue," Emery told reporters at a press conference.
"Tomorrow's game is very important but it would be a big loss if he could not play in the matches that follow."
Valencia face Atletico Madrid in the Europa League on Thursday but the coach stated his team are focused solely on Espanyol.
"It would be a mistake to play this game thinking about the first leg of the Europa League semi-finals. The team have to give their all in the league and in Europe," he added.
"We must be on high alert in the game against Espanyol. On their field they are strong and play an offensive style," he concluded.
Valencia are currently third in the Primera Division table, two points ahead of Malaga.