For Barcelona, Victor Valdes, Seydou Keita, Alexis Sanchez and Thiago Alcantara all have four bookings, and would incur a one-match ban if they receive another yellow card.
For Real Madrid, meanwhile, Cristiano Ronaldo, Xabi Alonso and Fabio Coentrao are also on the threshold of a ban leading up to the decisive game at Camp Nou in 12 days time.
With both sides having to play two games beforehand, there is a chance for some players to clear their names before the potential league decider with a booking in the midweek fixtures coming up.
However, the league's competition committee is likely to be watching closely, after Madrid were punished last season in the Champions League with Alonso and Sergio Ramos deliberately getting themselves sent off in a 4-0 win against Ajax, following instructions from coach Jose Mourinho in order to miss their last group game.
Madrid travel across the capital to face Atletico on Wednesday, before hosting Sporting Gijon on Sunday, while Barca welcome Getafe on Tuesday and then travel to Valencia on Sunday to meet Levante.
Starting last month and continuing for 10 weeks, Goal.com is publishing exclusive extracts from Luca Caioli's new book, Ronaldo: The Obsession for Perfection. The third extract, published on Friday, looks at Ronaldo's trial and subsequent signing for Sporting Lisbon at the age of 12. Don't miss it!