The captain has failed to overcome the damage sustained in Wednesday's 3-2 victory over Reading, with David Luiz stepping in, while Fabricio Coloccini returns for the visitors
The captain has been struggling to overcome the injury sustained against Reading in midweek.
However, the Brazilian defender David Luiz steps in after sitting out the 4-2 victory, with Frank Lampard and Ramires dropping to the bench.
Alan Pardew has made nine changes from the side that claimed a 1-1 in their Europa League qualifier against Atromitos.
Among the new faces is captain Fabricio Coloccini, who has recovered from a thigh injury.
Chelsea: Cech; Ivanovic, Cahill, David Luiz, Cole; Mikel, Meireles; Mata, Hazard, Bertrand; Torres.
Subs: Turnbull, Essien, Romeu, Lampard, Ramires, Oscar, Sturridge.
Newcastle: Krul; Simpson, S Taylor, Coloccini, Santon; Ben Arfa, Cabaye, Anita, Gutierrez; Ba, Cisse.
Subs: Harper, Williamson, Perch, Marveaux, Amalfitano, Obertan, R Taylor.