The Amsterdam club's captain, who has been heavily linked with a move to England this summer, has won the prestigious accolade after helping his side lift their 31st league title
The Belgium international beat off competition from Heerenveen's Bas Dost, Feyenoord's Jordy Clasie and team-mate Christian Eriksen to win the prestigious award, which he will add to the Player of the Year accolade he received from his own club just a few weeks ago.
The 25-year-old Vertonghen played a key role in Ajax claiming their 31st Eredivisie title this season, marshalling a defence which kept 11 clean sheets in total, as well as chipping in with an impressive seven goals.
However, while the centre-back still has another year to run on his contract, he is expected to leave Amsterdam this summer, having been repeatedly linked with a move to Tottenham.
Vertonghen, who arrived at Ajax as a teenager from Antwerp outfit Germinal Beerschot, announced on Sunday that he is also considering offers from elsewhere.