Stuart Taylor's side welcome Bray Wanderers to Thomond Park for their league opener, with Barry Ryan set to miss out for the hosts
Both sides have lost big names over the off-season in Joe Gamble and Jason Byrne respectively, but with the emergence of Ishmahil Akinade for the Seagulls and newly-appointed Limerick captain Shane Duggan returning to his hometown club, both sides have reasons to be positive.
Limerick will be without Barry Ryan (meningitis) and Mick Leahy (minor injury), while doubts hang over the fitness of Sam Oji and Robbie Williams.
Bray will have to make do without Shane O'Neill and Adam Mitchell who miss out through injury while Graham Kelly, Shane O'Connor and Dave Scully are all sidelined through suspension.
Limerick manager Stuart Taylor is feeling optimistic of getting the season off to a good start. "The second season is always tougher," he told the club's official website.
"We're looking forward to it. They [Bray] will set out their stall to try and stop us - they know we'll try and play good football, but it's upto us. The players are more than good enough to be successful."
Bray boss Alan Mathews believes the squad he has assembled good enough to be competitive. "Pre-season has gone pretty well, I've been happy with the players' attitude and application," said Mathews.
"We're looking forward to Friday night. It's a tough assignment but it's a good place to go and play."