The Scots, who sit bottom of World Cup qualifying Group A, can overtake their eastern European opponents with a win - though neither will be appearing in Brazil next summer
Cedomir Janevski's men have three games left but Tuesday's visit of the group's bottom side signals their final match on home soil.
The 2014 World Cup in Brazil is already beyond their reach but third-placed Serbia are just one point ahead, having played a game more.
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Scotland are 13/1 with BetVictor to beat Macedonia 2-1
Ivan Trickovski and Aleksandar Trajkovski were on target as Gareth Bale, the world's most expensive player, remained on the bench for the visitors.
The result saw Scotland slip to the foot of Group A, as they were overcome 2-0 by a superior Belgium side at Hampden Park, with Macedonia moving up two places.
And Scotland manager Gordon Strachan admitted that the Belgians were simply too good a proposition for his side.
"That's the best team we've played since I took over," he said. "Belgium were magnificent.
"It was like a heavyweight boxer up against a flyweight. They've got speed, height, strength - and we don't."
Scotland come into this game having only won once during their campaign, and Strachan will be keen to rectify that in order to avoid finishing at the bottom of the group.
Macedonia are sure to pose a challenge, though, as they look for their third straight international victory.
The two sides played out a well-contested 1-1 draw when they met at Hampden Park last September, after Kenny Miller cancelled out Nikolce Noveski's early opener.