The toast of the weekend in the knockout competition is the encounter between Liberty Professionals and Amidaus whiles Hearts move to Tamale to face Utrecht
Amidaus beat Liberty 2-0 in the first round of the Ghana Premier League and have been churning out some brilliant performances in their maiden top flight campaign.
Head coach Tony Lokko told Goal.com Ghana that Saturday’s game will be a test of character for his side.
Meanwhile, Liberty Professionals manager George Lamptey thinks his charges must dig deep to win the encounter.
Another tie which promises to be a cagey one is the match between Aduana Stars and RTU.
In Tamale, soccer fans in the Northern belt will be privileged to see the new look Accra Hearts of Oak ahead of the second round of the Premier League when they trek to Tamale to take on Division one side Tamale Utrecht.
League champions Asante Kotoko will have to wait until Wednesday to tackle either Japekrom or Dormaa Nkyenkyenkye.
In some selected fixtures, former Premier League side Feyenoord tackle Wassaman at Gomoa Fetteh while Ebusua Dwarfs host Hasaacas in Cape Coast.
Premier League side Heart of Lions will face third-tier side Kutunse FC at Kpando while Tema Youth travel to Sekondi to play Dumas FC at the Gyandu Park.