The 29-year-old who is on loan at Real Madrid from Chelsea said his desire to sort out his long-term future at club level will not allow him to be in South Africa.
Ghana coach, Kwesi Appiah was hoping to get the former Lyon player to bolster his squad as the Black Stars seek to end the 31-year-old trophy drought.
"Essien has made it clear to me he is still committed to playing for Ghana but he wants to sort out his club issues after moving from Chelsea to Real Madrid on loan," Appiah told the BBC.
“He is playing regularly now for Madrid and needs time to establish himself."
The ‘Bison’ is yet to clearly state when he will return to the team after going on international break since June 2011, but he hinted he could be back when the 2014 World Cup qualifiers begin.
Appiah seems to understand the player’s situation after he suffered series of career threatening injuries in recent times that kept him inactive at Chelsea until he joined Los Blancos just this season.