Ghana defender Harrison Afful and striker Emmanuel Clottey will end the season in Tunisia with medals after their side Esperance Sportive de Tunis clinched the league title.
Going into the final round of matches, the two-time African champions have a five-point gap which automatically makes them champions.
Esperance beat Club Africain 3-2 on Wednesday to maintain the five point advantage with Afful lasting 59 minutes in the game.
The left-back has ended all his seasons at the Tunisian giants with the league title ever since joining them in 2009.
Emmanuel Clottey, the highly rated striker on the continent, joined the Blood and Gold a few weeks ago from Berekum Chelsea and spent very little time in landing a medal.
The leading scorer in the Caf Champions League with 12 goals made his debut for the Tunisian giants last week.