The injury-prone striker was forced off after taking two knees to the thigh in a challenge against Hungary, although boss Louis Van Gaal has played down the extent of the injury
Van Persie took two knees to the thigh in a challenge with Hungary defender Roland Juhasz and was replaced by Klaas-Jan Huntelaar during the interval. The extent of the Dutchman's injury has not yet been confirmed.
But speaking after the match - which the Netherlands won 4-1 thanks to goals from Bruno Martens, Klaas-Jan Huntelaar and a double from Jeremain Lens - boss Louis van Gaal insisted the former Arsenal man's early withdrawal is nothing to worry about.
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The 29-year-old has netted four goals in three games for United following his transfer from Arsenal last month. Van Persie also scored in Netherlands' 2-0 World Cup qualifying victory against Turkey on Friday.
United will be hoping he returns to full fitness in time for the visit of Wigan on Saturday, while fellow summer arrival Shinji Kagawa is also a concern after missing Japan's World Cup qualifier against Iraq with a back injury.