Spurs manager Andre Villas-Boas has taken the competition seriously this season, and his side are valued at just 4/9 (1.44) to progress with Paddy Power.
Lyon have home advantage though, and are available at 13/8 (2.63) to overturn a first-leg deficit and qualify for the next round. They are slightly shorter at 13/10 (2.30) to win the match over 90 minutes though.
Tottenham won the first leg outright thanks to a double from Gareth Bale, and the north London outfit can be backed for victory again in this match at 11/5 (3.20).
The draw is at 9/4 (3.25), although none of the two club's previous three meetings have ended in a stalemate.
With Lyon showing promise in the first leg before falling to a Bale masterclass, it is hard to predict a winner in this game even if Tottenham are the more likely team to progress.
Instead, backing both teams to score looks a wise selection at 4/6 (1.66), considering only once in each side's last eight games have Tottenham and Lyon fired a blank.
Lyon hit four past Bordeaux at the weekend, while Spurs enjoyed an FA Cup weekend off and should be well rested as a result.
Both teams try to play exciting football, and seeing the both teams find the net will come as no surprise.
The man most likely to get a goal for this Tottenham side is Bale, who has scored every one of Spurs' last six goals in all competitions.
The Wales international is in great goal-scoring form and as a value bet at 11/4 (3.75) punters should not miss out on backing him to score Tottenham's first goal in south-west France.
|Both teams to score at 4/6 (1.67) with Paddy Power
||Gareth Bale to score first for Tottenham at 11/4 (3.75) with Paddy Power|
Jamie Dickenson is a 22-year-old freelance journalist who specialises in football, sports and betting.
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