Four Premier League sides - Arsenal, Everton, Manchester City and Wigan - face lower-league opponents, while Manchester United and Reading go head-to-head on Monday.
And if you place a five-fold or bigger accumulator bet on the Both Teams to Score market for Saturday and Sunday's FA Cup matches and if only one leg lets you down, Paddy Power will refund your losing bet.
Arsenal are first up on Saturday afternoon and are 2/7 (1.29) with Paddy Power to see of Blackburn at Emirates Stadium. With a crucial Champions League game against Bayern Munich to come on Tuesday, manager Arsene Wenger will want this tie resolved with the minimum of fuss if possible.
The Gunners boss may be tempted to rest a couple of players and with Jordan Rhodes scoring regularly since his move from Huddersfield he could trouble Arsenal’s defence. Paddy Power offer 4/6 (1.67) that both teams will score in this game.
Oldham entertain Everton on Saturday after claiming cross-city rivals Liverpool’s scalp in round four, the League One side will fancy their chances at Boundary Park.
This is David Moyes’ side third game on the road in the FA Cup this season and the last time that happened was in the 1989/90 season when Everton went out in the fifth round – to Oldham.
Paddy Power make it 5/6 (1.83) that both teams score and if Oldham score first, Paddy Power will refund all losing First/last goalscorer, correct score & scorecast singles on the match.
Huddersfield – who have appointed former Coventry manager Mark Robins - beat Leicester 2-1 away on Tuesday night to set up a clash with Wigan at the John Smiths's stadium. Paddy Power are 4/6 (1.67) that both sides score and Wigan will need to be on their guard if they’re to progress.
Spurs, along with Liverpool, were the biggest casualties in the fourth round losing to Leeds at Elland Road and Neil Warnock’s side have earned another big pay-day against Premier League champions Manchester City in round five.
The hosts' chances of retaining the Premier League appears to have almost disappeared after their 3-1 defeat at Southampton last weekend and the FA Cup is their only chance of silverware this season.
Leeds deserved their win against Spurs and while a home tie would have increased their chances of another upset considerably and their strikers, such as Ross McCormack, do pose a very real goal threat. Paddy Power are offering Evens (2.0) that both sides score.
Holders Chelsea get a second bite of the cherry against near-neighbours Brentford in their fourth-round replay on Sunday with the winner away to Middlesbrough next Wednesday.
With the Premier League out of reach this is a realistic chance for the Blues to claim a trophy this season and Rafa Benitez will be keen to do so. Paddy Power make it 10/11 (1.91) both teams to score.
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Jim Knight is Betting Editor at Goal.com and has been tipping football games since he was old enough to place a bet. He is a Leicester City fan, writer and member of the We Are Going Up Podcast
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