The Juventus midfielder insists that his side never tire of securing a win over their local rivals and intends to add another victory when the two teams meet on Sunday
The Bianconeri boast an impressive record against their neighbours, with Toro losing their previous five Serie games against them and failing to register a victory in the derby since 1995.
However, Giampiero Ventura's side go into the game with confidence after their 3-1 win over Hellas Verona last week pushed them into sixth, just three points behind Inter in the final Europa League spot.
Speaking ahead of the encounter though, Marchisio stressed that there was no doubting the desire of the Old Lady to collect another three points against the side they overcame 1-0 in September's derby.
"With Juve I've played and taken some great satisfaction from winning in the derby," the 28-year-old Italian told the club's official YouTube channel.
"There's only one problem - it's not enough for us. It's never enough!"
Juventus have won all 12 of their Serie A home games this season and go into the fixture with no sign of their form waning after securing a 2-0 last-32 Europa League win over Trabzonspor on Thursday.
The defending champions sit top of the league with 63 points from 24 games, six ahead of second-placed Roma.