The Spurs boss suggested attack will be the best form of defence against Manuel Pellegrini's men, while indicating he wants to keep hold of both Lewis Holtby and Etienne Capoue
When the two sides met at the Etihad Stadium in November, Manuel Pellegrini's men ran out 6-0 winners, a result that signalled the beginning of the end for former Spurs boss Andre Villas-Boas.
However, Sherwood has got a plan to stop City adding to their 63 league goals so far this season, telling his troops that attack is the best form of defence.
He told reporters: "We can't worry about them, we have to be responsible to make sure we're concentrated and defend very well at all times.
"But I think we also need to see if there's anything we can do to affect them. And there is. There will be weaknesses in their play and hopefully we can try and exploit some of them.
"If you don't stem the flow, they can be home and dry very quickly. We can't afford a capitulation like we saw at the Etihad.
"Their biggest strength, Man City, is when they attack. So let's hope that we can try and make them defend as much as possible."
Sherwood was also keen to stress Lewis Holtby and Etienne Capoue would be staying at White Hart Lane, and were both pushing for starting roles, despite respective January links to Schalke and Napoli.
"I'm happy with the squad we've got," he added. "I do trust this group of players to take us to where we need to be.
"I like Lewis, he's a good lad [and is] one of the best trainers we have. [It's the] same with Etienne, he's a good lad and a good trainer. He's not given me a moment's problem and I don't expect him to be a problem.
"I'm getting to know Etienne now as well. So he's at the forefront of my mind at the moment."