Gunners boss Arsene Wenger has confirmed that the former Malaga playmaker picked up a knock with the Spanish national team and will be out of action until next month
The forward picked up the problem while on duty with Spain in midweek, and is unlikely to play again until the next round of World Cup qualifiers are completed.
"Cazorla has an ankle problem," Wenger said after the 3-1 win over Sunderland. "He will be out for a few weeks as well.
He added: "I don't think he will play before the next international break."
The Gunners boss also confirmed fears that Olivier Giroud may have picked up a knee injury during the victory at the Stadium of Light.
"That's my worry [that Giroud is injured], today, after the game," he said. "We are very thin at the moment.
"It's a knee problem. He is the player at the moment who we cannot lose."
Giroud struck the opening goal in Arsenal's victory over Sunderland, meaning he has scored in four consecutive league games for the Gunners, with a double from Aaron Ramsey securing the three points.