Sir Alex Ferguson gives his two wingers a start with Rio Ferdinand and Jonny Evans returning in defence for the trip to London to face Martin Jol's men
The duo are part of six changes from the team that narrowly beat Southampton 2-1 in midweek. In defence Rafael, Rio Ferdinand and Jonny Evans return while Tom Cleverley comes into the midfield.
Fulham make just two changes with Chris Baird and Ashkan Dejagah coming in for Sascha Riether and Steve Sidwell. New signing Urby Emmanuelson is on the bench while the injured Dimitar Berbatov misses out against his former team.
Fulham: Schwarzer; Riether, Hangeland, Senderos, Riise; Dejagah, Baird, Karagounis, Duff; Ruiz, Rodallega.
Subs: Etheridge, Hughes, Frimpong, Emanuelson, Davies, Kacaniklic, Petric
Manchester United: De Gea, Rafael, Ferdinand, Evans, Evra, Carrick, Cleverley, Nani, Rooney, Valencia, Van Persie.
Subs: Amos, Anderson, Giggs, Smalling, Hernandez, Welbeck, Kagawa.