The Bulgarian left the Red Devils for the Cottagers in the summer and lines up against his former side looking for their 125th home win in the history of the FA Cup
The Bulgarian left the Red Devils in the summer and has scored seven goals in 20 games for the Cottagers so far this season.
Bryan Ruiz partners the Bulgarian in attack, while John Arne Riise returns to the Fulham line-up after recently being dropped due to poor form.
The hosts start with Wayne Rooney and Chicharito in attack, while Ryan Giggs features on the left-hand side of midfield.
Phil Jones drops into defence, where he is partnered by Chris Smalling in the heart of United's backline.
Manchester United starting XI: De Gea; Rafael, Jones, Smalling, Evra; Nani, Anderson, Carrick, Giggs; Rooney, Chicharito.
Subs: Ferdinand, Valencia, Lindegaard, Welbeck, van Persie, Scholes, Kagawa.
Fulham starting XI: Schwarzer; Riether, Hangeland, Hughes, Riise; Duff, Sidwell, Baird, Kacaniklic; Ruiz; Berbatov.
Subs: Senderos, Petric, Karagounis, Briggs, Rodallega, Dejagah, Etheridge.