The Belgium international was hurt in the 1-1 Champions League draw with Real Madrid on Wednesday after a tussle with Cristiano Ronaldo during the latter stages of the game, and recieved treatment after the final whistle before leaving the Etihad Stadium on crutches.
Kompany will be assessed on Saturday before a decision is made over whether he can play, but Mancini is remaining optimisitic that he will be able to lead the Premier League leaders out at at Stamford Bridge in a crunch top of the table clash.
“I hope Vinnie can recover but we won’t know until tomorrow,” the Italian told the club's official website. “He is strong so there is a chance, but we will make a final decision on Saturday. Mario trained on Thursday so should be OK but Gael is still injured.”
Left-back Gael Clichy will not be travelling to west London after failing to shake off an ankle injury, but there was better news for Mancini after striker Mario Balotelli returned to training after sitting out the last two games with a back injury.