Chicharito partners the England striker in attack for Louis van Gaal's side while Brendan Rodgers sticks with Rickie Lambert
Darren Fletcher has previously been the recipient of the armband during pre-season, but, despite the Scottish midfielder's presence in the starting XI, it is Rooney who will lead out the side in Miami.
The England international is partnered up front by Javier Hernandez, even though the Mexican has been linked with a summer transfer, with Juan Mata in the hole.
Ashley Young, fresh from scoring against Real Madrid, continues at left wing-back, with Antonio Valencia on the right, while new recruit Ander Herrera is picked in midfield.
Liverpool, meanwhile, persist with Lambert despite his problematic start to life at Anfield, surprisingly missing a penalty last time out, and he will link up with Raheem Sterling.
Skipper Steven Gerrard is accompanied by Joe Allen and Jordan Henderson in midfield as Rodgers picks a strong side to try and claim ICC glory.
Manchester United starting XI: De Gea; Evans, Smalling, Jones; Valencia, Herrera, Fletcher, Young; Mata; Rooney, Chicharito.
Liverpool starting XI: Mignolet; Kelly, Johnson, Skrtel, Sakho; Gerrard, Allen, Henderson; Coutinho, Lambert, Sterling.