The Kenyan international injured his knee in pre-season and suffered a reaction after playing against Newcastle United and Chelsea at the start of the season.
The 26-year-old has been forced to rest and had been hoping to make the squad for the Champions League tie with Real Madrid.
Wanyama also missed out Harambee Stars’ friendly matches against Iraq and Thailand during the just concluded Fifa calendar. Kenya lost both matches 2-1 and 1-0 respectively.
But according to Daily Mail, the Premier League game with Liverpool on October 22 looks more realistic for the midfielder to make his long awaited comeback.
Tottenham will face Bournemouth this weekend prior to Madrid, Liverpool, West Ham and Manchester United this month.
Wanyama’s return will be great news for Spurs, who have certainly missed his marauding play in the center of midfield. Spurs have been really stretched in their midfield depth department the past few weeks, with both Wanyama and Mousa Dembele out.