Tottenham take on Chelsea at Wembley Stadium on Sunday in what will be the first ever Premier League match played at England's national stadium.
Spurs are playing their home games at the famous 'Home of Football' for the duration of the 2017-18 season as they wait for a new stadium to be built and they fittingly kick things off against London rivals Chelsea - a team they have frequently butted heads with in recent years.
Mauricio Pochettinho's men finished runners-up to the Blues last season as Antonio Conte's side swept to glory, but the two teams have begun the new campaign with contrasting fortunes. While the reigning champions began their title defence with a defeat away to Burnley, Tottenham made light work of Newcastle at St James' Park.
Given its timing, the game at Wembley represents an excellent opportunity for both teams to land an early blow in the battle for the league.
|Game||Tottenham vs Chelsea|
|Date||Sunday, August 20|
|Time||16:00 BST / 11:00 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will be available to watch live on television on Sky Sports Premier League and by via online stream using the Sky Go app.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
In the US, the match will be available to watch live on television on NBCSN, as well as being available to stream online using the NBC Sports App.
|US TV channel||Online stream|
|NBCSN||NBC Sports App|
SQUAD & TEAM NEWS
|Defenders||Alderweireld, Vertonghen, Walker-Peters, Davies, Wimmer, Trippier, Rose, Carter-Vickers|
|Midfielders||Alli, Dier, Dembele, Eriksen, Sissoko, Wanyama, N'Koudou, Winks, Lamela|
|Forwards||Janssen, Kane, Son|
Danny Rose and Erik Lamela remain unavailable as they recover from long-term injuries, while Kieran Trippier is also expected to miss out as he recovers from a minor sprain.
Heung-min Son made an appearance from the substitutes bench in the opening-day win over Newcastle and could be in line to start after seemingly making a return to full fitness.
Potential starting XI: Lloris; Walker-Peters, Vertonghen, Alderweireld, Davies; Dier, Dembele, Alli, Eriksen, Son; Kane.
|Goalkeepers||Courtois, Caballero, Eduardo|
|Defenders||Azpilicueta, Luiz, Christensen, Rudiger, Alonso, Tomori, Cahill|
|Midfielders||Kante, Moses, Willian, Pedro, Fabregas, Musonda, Scott, Hazard, Bakayoko, Pedro, Kenedy, Boga|
Cesc Fabregas and Gary Cahill are suspended for the game after both players were sent off in last weekend's defeat to Burnley. The Blues will also be without Diego Costa, who is agitating for a move to Atletico Madrid.
Eden Hazard and Tiemoue Bakayoko are in training following injuries, but neither are likely to feature against Spurs. There is good news for Conte as Victor Moses returns from suspension, while Pedro could also be fit to play.
Potential starting XI: Courtois; Rudiger, Luiz, Azpilicueta; Moses, Alonso, Christensen, Kante; Willian, Pedro, Morata.
BETTING & MATCH ODDS
Tottenham went the whole of the 2016-17 season unbeaten at home and they are 23/20 favourites to beat Chelsea, according to dabblebet. The Blues are priced at 13/5 to beat Spurs, while a draw is considered a 23/10 bet.
Last season's Golden Boot winner Harry Kane is the favourite to open the scoring at 10/3, while new Chelsea signing Alvaro Morata is an 11/2 bet to score first. Dele Alli and Michy Batshuayi can be backed at 13/2.
Tottenham were left trailing in Chelsea's wake last season as the Blues won the Premier League by seven points and knocked Spurs out of the FA Cup in the semi-final. Pochettino's men will be keen to avoid a repeat of that this season and they can issue a statement of intent by overcoming Conte's side on Sunday.
Despite losing Kyle Walker to Manchester City and failing to add reinforcements - the club are in talks to sign Davinson Sanchez from Ajax but a deal has yet to be confirmed - Spurs put in an impressive performance against Newcastle last week and they will be eager to take advantage of the disarray enveloping Chelsea following their embarrassing opening-day defeat to relegation candidates Burnley.
The champions are involved in a protracted dispute with Diego Costa, who is desperately attempting to expedite his departure from the club, and they have lost Nemanja Matic to Manchester United, while key man Eden Hazard is ruled out with an injury. As well as that, Conte will be unable to call upon Fabregas or Cahill, who both saw red in last week's loss.
This early-season clash between two of the division's top teams could well have a decisive impact on where the title ends up at the conclusion of the season and the magnitude of the occasion - not least because of the venue - will not be lost on either side.